Abstract: Diabetic foot ulcer (DFU) is one of the severe complications of diabetes mellitus, which often leads to amputation and seriously impairs patients′quality of life. It has complex etiology, involving vascular disease, neuropathy, and infection, etc., and western medical treatment options are limited. In traditional Chinese medicine (TCM), DFU is classified as "tuoju" (gangrene of the extremities). Simiao Yong′an Decoction, a commonly used formula, has demonstrated clinical effects in improving blood flow, repairing nerves, controlling infection, and promoting wound healing. This article reviewed the TCM pathogenesis of DFU and the clinical and experimental research progress of Simiao Yong′an Decoction, aiming to provide a scientific basis for its treatment.