高级检索

百会穴和关元穴压灸联合丁苯酞对脑卒中恢复期患者认知功能的影响

Effect of pressure moxibustion at Baihui and Guanyuan acupoints combined with butylphthalide on cognitive function in stroke patients in recovery phase

    摘要
  • 摘要:
    目的 探讨百会穴和关元穴压灸联合丁苯酞在脑卒中恢复期患者中的应用效果。
    方法 将108例脑卒中恢复期患者随机分为观察组和对照组，每组54例。对照组在常规治疗基础上采取丁苯酞治疗，观察组采取百会穴和关元穴压灸联合丁苯酞治疗，连续8周。疗程结束后评估2组疗效，比较2组治疗前后功能状态美国国立卫生研究院卒中量表(NIHSS)、蒙特利尔认知评估量表(MoCA)、Barthel指数(BI)、事件相关电位P300、血流动力学指标血管阻力指数(RI)、血管搏动指数(PI)、平均流速(Vm)水平、认知功能标志物脂蛋白相关磷脂酶A2(Lp-PLA2)、碱性磷酸酶(ALP)、人β淀粉样蛋白1-42(Aβ-42)水平及安全性。
    结果 观察组治疗总有效率为96.30%，高于对照组的85.19%, 差异有统计学意义(P < 0.05)。治疗8周后，观察组MoCA、BI高于对照组, NIHSS低于对照组，差异均有统计学意义(P < 0.05)。治疗8周后，观察组潜伏期低于对照组，波幅以及治疗前后潜伏期差值、波幅差值均高于对照组，差异有统计学意义(P < 0.05)。治疗8周后，观察组Vm高于对照组, PI、RI低于对照组，差异均有统计学意义(P < 0.05)。治疗8周后，观察组Lp-PLA2、ALP、Aβ-42水平低于对照组，差异有统计学意义(P < 0.05)。2组患者均未出现严重不良反应。
    结论 百会穴、关元穴压灸联合丁苯酞可改善脑卒中恢复期患者脑血流，促进认知功能、神经功能恢复，其机制可能与Lp-PLA2、ALP、Aβ-42表达下调有关。

     

    Abstract:
    Objective To explore the application effect of pressure moxibustion at Baihui and Guanyuan acupoints combined with butylphthalide in treating stroke patients in recovery phase.
    Methods A total of 108 stroke patients in recovery phase were randomly divided into observation group and control group, with 54 cases in each group. The control group was treated with butylphthalide on the basis of conventional treatment, while the observation group was treated with pressure moxibustion at Baihui and Guanyuan acupoints combined with butylphthalide for 8 consecutive weeks. After the end of the treatment course, the efficacy was evaluated in both groups, and the functional statusthe National Institutes of Health Stroke Scale (NIHSS), the Montreal Cognitive Assessment (MoCA), the Barthel Index (BI), event-related potential P300, the levels of hemodynamic indicatorsresistance index (RI), pulsatility index (PI), mean velocity (Vm), cognitive function markerslipoprotein-associated phospholipase A2 (Lp-PLA2), alkaline phosphatase (ALP), human β-amyloid 1-42 (Aβ-42) and safety were compared between the two groups before and after treatment.
    Results The total effective rate in the observation group was 96.30%, which was significantly higher than 85.19% in the control group (P < 0.05). After 8 weeks of treatment, the MoCA and BI scores in the observation group were significantly higher than those in the control group, while the NIHSS score was significantly lower (P < 0.05). After 8 weeks of treatment, the latency in the observation group was significantly lower than that in the control group, while the amplitude and the differences in latency and amplitude before and after treatment were significantly higher (P < 0.05). After 8 weeks of treatment, Vm in the observation group was significantly higher than that in the control group, while PI and RI were significantly lower (P < 0.05). After 8 weeks of treatment, the levels of Lp-PLA2, ALP and Aβ-42 in the observation group were significantly lower than those in the control group (P < 0.05). No serious adverse reactions occurred in patients in each group.
    Conclusion Pressure moxibustion at Baihui and Guanyuan acupoints combined with butylphthalide can improve cerebral blood flow and promote the recovery of cognitive and neurological functions in stroke patients in recovery phase. The mechanism may be related to the downregulation of Lp-PLA2, ALP and Aβ-42 expression.

     

    • HTML全文
    • 参考文献(26)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回