Abstract: Acute myeloid leukemia (AML) is one of the common subtypes of acute leukemia, characterized by complex pathogenesis, poor clinical prognosis, and low cure rate. The gut microbiota plays a crucial role in maintaining host immune homeostasis, regulating inflammatory responses, and influencing tumor initiation and progression. Gut microbiota dysbiosis is closely associated with the occurrence and development of AML. It may serve as an important target for precision treatment of AML. Understanding the relationship between gut microbiota dysbiosis and AML is of great significance for the clinical management of AML. This review aimed to summarize recent research progress in the correlation between gut microbiota dysbiosis and AML and explore its potential role in the pathogenesis of AML.