Abstract: Pulmonary infection is one of the infectious diseases that have long plagued human health. The receptor for advanced glycation end-products (RAGE) is a non-specific, multi-ligand pattern recognition receptor expressed on the surface of various tissues and cells. It can bind to a series of structurally different ligands, including pathogen-associated molecular patterns from pathogenic microorganisms. Soluble receptor for advanced glycation end-products (sRAGE) is a soluble form generated when cell surface RAGE is excessively stimulated by inflammatory cytokines. As a competitive receptor, it inhibits multiple RAGE-dependent cellular signaling pathways and participates in the inflammatory response process. This review summarized the clinical significance of serum sRAGE levels in infection-related pulmonary diseases, explored the biological characteristics of sRAGE in these diseases, and evaluated its clinical application value.