Abstract:
Objective To integrate multi-source heterogeneous literature data from China National Knowledge Infrastructure (CNKI), Wanfang, VIP, and Web of Science (WoS) databases using bibliometric methods, and to comparatively analyze the differences in knowledge structure characteristics and evolutionary pathways of organoid research between China and foreign countries.
Methods CiteSpace software was employed to conduct a visual atlas analysis of the publication volume, countries, institutions, authors, and keywords of 1, 118 Chinese literatures and 10, 871 English literatures.
Results China ranked the second globally in terms of publication volume (accounting for 22.09%), but exhibited low centrality in international collaboration networks. The density of the domestic institutional collaboration network was 0.003, indicating a relatively loose structure, with Fudan University leading domestic output with 15 Chinese papers. Keyword emergence analysis revealed that "organ-on-a-chip" and "biomechanics" have emerged as new hotspots since 2024.
Conclusion It is recommended to establish an interdisciplinary collaborative innovation alliance to focus on breakthroughs in the translational directions of organ-on-a-chip and biomechanics, thereby addressing the imbalance between "scale and quality" in China′s organoid research.
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