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超声弹性成像与血清癌胚抗原、解整合素金属蛋白酶12、糖类抗原125联合诊断乳腺癌的价值

Value of combined diagnosis of breast cancer by ultrasound elastography, serum carcinoembryonic antigen, a disintegrin and metalloproteinase 12 and carbohydrate antigen 125

    摘要
  • 摘要:
    目的 探讨超声弹性成像(UE)联合血清癌胚抗原(CEA)、解整合素金属蛋白酶12(ADAM12)、糖类抗原125(CA125)在乳腺癌诊断中的应用价值及其与临床病理特征的相关性。
    方法 选取120例乳腺癌患者作为研究组, 另选取同期120例乳腺良性病变患者作为对照组。比较2组患者的UE评分和血清CEA、ADAM12、CA125水平; 分析研究组患者UE评分与血清CEA、ADAM12、CA125水平的相关性; 比较研究组不同病理特征患者的UE评分和血清CEA、ADAM12、CA125水平; 分析UE评分和血清CEA、ADAM12、CA125水平与乳腺癌病理特征的相关性; 绘制受试者工作特征(ROC)曲线，评估UE评分和血清CEA、ADAM12、CA125水平单独及联合诊断乳腺癌的价值。
    结果 研究组患者的UE评分和血清CEA、ADAM12、CA125水平均高于对照组，差异有统计学意义(P < 0.05); 研究组患者UE评分与血清CEA、ADAM12、CA125水平均呈正相关(P < 0.05); 研究组不同临床分期、有无淋巴结转移患者的UE评分和血清CEA、ADAM12、CA125水平比较，差异有统计学意义(P < 0.05); UE评分和血清CEA、ADAM12、CA125水平均与乳腺癌临床分期、淋巴结转移情况呈正相关(P < 0.05); UE评分、CEA、ADAM12、CA125联合诊断乳腺癌的曲线下面积(AUC)为0.918，显著大于各指标单独诊断的AUC(P < 0.05)。
    结论 UE评分和血清CEA、ADAM12、CA125水平均与乳腺癌临床分期、淋巴结转移情况呈正相关，四者联合应用可显著提高对乳腺癌的诊断效能。

     

    Abstract:
    Objective To investigate the application value of ultrasound elastography (UE) combined with serum carcinoembryonic antigen (CEA), a disintegrin and metalloproteinase 12 (ADAM12) and carbohydrate antigen 125 (CA125) in the diagnosis of breast cancer and their correlations with clinicopathological features.
    Methods A total of 120 patients with breast cancer were selected as study group, and another 120 patients with benign breast lesions during the same period were selected as control group. The UE scores and serum levels of CEA, ADAM12, and CA125 were compared between the two groups. The correlations of UE scores with serum levels of CEA, ADAM12 and CA125 in the study group was analyzed. The UE scores and serum levels of CEA, ADAM12 and CA125 were compared among patients with different pathological features in the study group. The correlation of UE scores, serum levels of CEA, ADAM12 and CA125, with the pathological features of breast cancer were analyzed. Receiver operating characteristic (ROC) curves were plotted to evaluate the value of UE scores and serum levels of CEA, ADAM12 and CA125 in the individual and combined diagnosis of breast cancer.
    Results The UE scores and serum levels of CEA, ADAM12 and CA125 in the study group were significantly higher than those in the control group (P < 0.05). The UE scores in the study group were positively correlated with the serum levels of CEA, ADAM12 and CA125 (P < 0.05). There were significant differences in the UE scores and serum levels of CEA, ADAM12, and CA125 among patients with different clinical stages and those with or without lymph node metastasis in the study group (P < 0.05). The UE scores and serum levels of CEA, ADAM12 and CA125 were positively correlated with the clinical stage and lymph node metastasis of breast cancer (P < 0.05). The area under the curve (AUC) for the combined diagnosis of breast cancer by UE scores, CEA, ADAM12 and CA125 was 0.918, which was significantly larger than that for the individual diagnosis (P < 0.05).
    Conclusion The UE scores and serum levels of CEA, ADAM12 and CA125 are positively correlated with the clinical stage and lymph node metastasis of breast cancer. The combined application of these four indicators can significantly improve the diagnostic efficacy for breast cancer.

     

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