Objective To explore and analyze the application effect of enzymatic debridement combined with traditional Chinese medicine fumigation-sitting bath therapy on postoperative wounds of perianal abscess.

Methods Eighty patients with simple perianal abscess were randomly divided into observation group (enzymatic debridement + traditional Chinese medicine fumigation-washing) and control group (potassium permanganate sitting bath + conventional debridement), with 40 cases in each group. The white blood cell (WBC) count, C-reactive protein (CRP) levels, wound healing rate, Visual Analogue Scale (VAS) pain score, and wound-related symptoms were observed in both groups after surgery.

Results WBC and CRP levels in the observation group were lower than those in the control group. The observation group showed superior results compared to the control group in terms of wound pain, edema, exudation, and wound healing rate. Additionally, the improvement in wound area, healing time, and longitudinal wound diameter in the observation group was significantly better than that in the control group (P < 0.05).

Conclusion Enzymatic debridement combined with traditional Chinese medicine fumigation-washing can accelerate wound healing, alleviate pain and inflammatory responses after perianal abscess surgery, showing superior efficacy compared to traditional methods.