Objective To conduct a bibliometric and visual analysis of literature related to antimicrobial therapy for febrile neutropenia (FN) in recent years and explore the research trends and hotspots in this field.

Methods The Web of Science database was searched to analyze the publication trends, countries/regions, research institutions, journal distributions, author influences, and keyword co-occurrences. VOSviewer, CiteSpace, and Scimago Graphica software were utilized for mapping analysis to present the research hotspots and development trends of antimicrobial therapy for FN.

Results A total of 536 articles were included. The average annual number of publications was approximately 43 from 2014 to 2019 and approximately 54 from 2020 to 2024, showing an upward trend. The United States had the highest number of publications (134 articles, accounting for 25.00%). The institution with the most publications was the University of Melbourne (18 articles). The author with the most publications was GUDIOL C (9 articles). Keyword clustering analysis revealed that the research hotspots were mainly concentrated in areas such as "febrile neutropenia", "antimicrobial stewardship", "immunocompromised hosts", "risk assessment", "cost-effectiveness analysis", "empirical therapy" and "Staphylococcus aureus".

Conclusion The number of publications on research related to antimicrobial therapy for FN has shown an upward trend in recent years. Antimicrobial stewardship, treatment of immunocompromised hosts, control of drug resistance, and personalized therapy may become the main research directions in the future.