Objective To investigate the effects of Bazhen Decoction combined with music intervention on fatigue severity and sleep quality in chemotherapy lung cancer patients.

Methods A total of 148 lung cancer patients undergoing chemotherapy were randomly divided into single-treatment group and combined-treatment group, with 74 cases in each group. Both groups received chemotherapy with vinorelbine tartrate injection and cisplatin. The single-treatment group received routine nursing care after chemotherapy. The combined-treatment group received music intervention combined with Bazhen Decoction in addition to routine nursing care. After three chemotherapy cycles, adverse emotions, fatigue severity, sleep quality, and quality of life were evaluated and compared between the two groups.

Results Before treatment, there were no statistically significant differences in the scores of appetite loss, Karnofsky Performance Status Scale (KPS), Patient-Generated Subjective Global Assessment (PG-SGA), Revised Piper Fatigue Scale (PFS-R), Pittsburgh Sleep Quality Index (PSQI), and Quality of Life Questionnaire (EORTC QLQ-C30) between the two groups (P>0.05). After treatment, the PG-SGA, PFS-R, and PSQI scores in both groups significantly decreased, and the scores in the combined-treatment group were significantly lower than those in the single-treatment group (P < 0.05). After treatment, the score of appetite loss, KPS, and the physical, emotional, social, and cognitive function scores in the EORTC QLQ-C30 significantly increased in both groups, and the scores in the combined-treatment group were significantly higher than those in the single-treatment group, with statistically significant differences (P < 0.05).

Conclusion Bazhen Decoction combined with music intervention can effectively alleviate adverse emotions in lung cancer patients undergoing chemotherapy, improve their quality of life, effectively reduce cancer-related fatigue caused by chemotherapy drugs, and improve patients' sleep quality.