Objective To observe the therapeutic efficacy of Jisheng Shenqi Pills combined with endocrine therapy in alleviating lower urinary tract obstruction symptoms of patients with advanced prostatecancer (PCa).

Methods A total of 68 patients with advanced PCa complicated by lower urinary tract obstruction symptoms were randomly divided into observation group and control group, with 34 cases in each group. The control group received endocrine therapy alone, while the observation group received Jisheng Shenqi Pills on the basis of the control group. Both groups underwent a course of 3-month treatment. The total therapeutic effectiveness rate, traditional Chinese medicine (TCM) syndrome scores, maximum urinary flow rate (Q_max), residual urinary volume (RUV), International Prostate Symptom Score (IPSS), prostate-specific antigen (PSA) levels, and Quality of Life (QOL) Scale scores were compared between the two groups.

Results The total therapeutic effectiveness rate in the observation group was 94.12%, which was significantly higher than 82.35% in the control group (P < 0.05). After treatment, TCM syndrome scores decreased in both groups, with the observation group had significantly lower scores than the control group (P < 0.05). Both groups exhibited an increase in Q_max and a decrease in RUV after treatment, with the observation group had significantly higher Q_max and lower RUV compared to the control group (P < 0.05). PSA level decreased significantly in both groups after treatment (P < 0.05), but no significant difference was observed between the two groups (P>0.05). IPSS score was decreased while QOL score was increased in both groups after treatment, with the observation group had significantly lower IPSS score and higher QOL score compared to the control group (P < 0.05).

Conclusion Jisheng Shenqi Pills combined with endocrine therapy effectively alleviates urinary obstruction symptoms, improves TCM syndromes, and enhances quality of life in patients with advanced PCa.