Abstract: Objective To explore the effect of interest induction combined with integrated healthcare nursing on improvements of mental health and prognosis in children with lobar pneumonia. Methods A total of 126 children diagnosed as lobar pneumonia in the Hebei Children's Hospital from October 2023 to October 2024 were selected as research objects and randomly divided into study group (n=63) and control group (n=63). The control group received conventional nursing interventions, while the study group received the interest induction combined with integrated healthcare nursing model. The time for improvement of clinical symptoms, psychological scores, therapeutic compliance, and the occurrence of complications were compared between the two groups. Results The resolution time for fever, obvious alleviation time for cough, relief time for shortness of breath, and disappearance time for moist rales in the study group were significantly shorter than those in the control group (P < 0.05). After the intervention, the scores of the Multidimensional Anxiety Scale for Children (MASC-C) and the Child Behavior Checklist (CBCL) in both groups were significantly lower than those before the intervention, and the scores in the study group were significantly lower than those in the control group (P < 0.05). The compliance scores of the study group in terms of taking medication on time, functional exercise, dietary adjustment, and self-monitoring dimensions were all significantly higher than those of the control group (P < 0.05). In the study group, there was 1 case of atelectasis and 1 case of pneumothorax, with a total complication rate of 3.17% (2/63); there was 1 case of pleural effusion, 1 case of atelectasis, and 2 cases of pneumothorax in the control group, with a total complication rate of 6.35% (4/63). There was no significant difference in the total complication rate between the two groups (χ²=0.700, P>0.05). Conclusion The interest induction combined with integrated healthcare nursing model can improve therapeutic compliance, shorten the time for improvement of clinical symptoms, and enhance the mental health of children.