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2015—2025年肠道菌群与认知功能障碍演进: 文献计量学与知识图谱分析

Evolution of gut microbiota and cognitive dysfunctionfrom 2015 to 2025: a bibliometric and knowledge mapping analysis

    摘要
  • 摘要:
    目的 分析2015-2025年肠道菌群和认知功能障碍研究领域的发展趋势、研究现状和热点, 为该领域研究者提供更全面参考, 并探究前沿研究方向。
    方法 检索WoSCC数据库相关研究领域文献, 利用VOSviewer、CiteSpace、ScimangoGraphica以及R软件包"bibliometrix"进行文献计量学分析和可视化分析。
    结果 从WoSCC数据库共检索出符合条件的英文文献665篇。分析结果发现, 自2018年开始, 出版物数量呈逐年增加趋势。中国和美国发文量及合作关系在世界范围内处于领先地位。Huazhong University of Science and Technology (华中科技大学)是该领域最具影响力的研究机构, 发文数量最多的期刊是NUTRIENTS(IF=4.8), 突出贡献及影响力排名第1位的研究者为KIM D H。关键词共现分析显示, "neuronal apoptosis" "SCFAs" "synaptic dysfunction" "dementia prevention"为该领域的研究热点。此外, 趋势分析发现, 肠道菌群重要代谢产物--短链脂肪酸、胰岛素抵抗以及神经炎症是该领域研究前沿, 揭示了胰岛素抵抗是菌群-认知研究的中介枢纽, 同时发现中医药干预(如电针)是该领域新兴特色方向。
    结论 本文通过文献计量学研究, 多角度分析了肠道菌群与认知功能障碍的研究现状和发展趋势, 为该研究领域的前沿动态提供了全面的见解, 也为更多学者在该领域的深入研究提供了有价值的参考。

     

    Abstract:
    Objective To analyze the development trends, research status, and hotspots in the field of gut microbiota and cognitive dysfunction from 2015 to 2025, providing a more comprehensive reference for researchers in this field and exploring cutting-edge research directions.
    Methods Literature in relevant research fields was retrieved from the WoSCC database. Bibliometric and visualization analyses were conducted using VOSviewer, CiteSpace, ScimangoGraphica, and the R package "bibliometrix".
    Results A total of 665 eligible English articles were retrieved from the WoSCC database. The analysis revealed that the number of publications has shown an increasing trend annually since 2018. China and the United States had the leading roles globally in terms of the number of publications and collaborative relationships. Huazhong University of Science and Technology are the most influential research institution in this field, with NUTRIENTS (IF=4.8) being the journal with the highest number of publications, and KIM D H ranking first in outstanding contributions and influence. Keyword co-occurrence analysis indicated that "neuronal apoptosis", "SCFAs", "synaptic dysfunction", and "dementia prevention" were the research hotspots in this field. Furthermore, trend analysis revealed that short-chain fatty acids (SCFAs), important metabolites of gut microbiota, insulin resistance, and neuroinflammation were the research frontiers in this field, highlighting insulin resistance as a mediating hub in microbiota-cognition research. Additionally, traditional Chinese medicine interventions (such as electroacupuncture) were identified as an emerging characteristic direction in this field.
    Conclusion Through bibliometric research, the current status and development trends of gut microbiota and cognitive dysfunction research are analyzed from multiple perspectives in the paper. Comprehensive insights into the cutting-edge dynamics of this research field are provided, offering valuable references for further in-depth research by more scholars in this area.

     

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