高级检索

基于限制性立方样条模型分析维生素D、氧化低密度脂蛋白与多囊卵巢综合征患者不孕的关系

Relationships of vitamin D and oxidized low-density lipoprotein with infertility in patients with polycystic ovary syndrome based on restricted cubic spline models

    摘要
  • 摘要:
    目的 基于限制性立方样条模型探讨维生素D、氧化低密度脂蛋白(ox-LDL)与多囊卵巢综合征(PCOS)患者不孕的关系。
    方法 选取150例PCOS患者作为研究对象，均随访至少1年，根据是否不孕分为不孕组与非不孕组。采用Logistic回归模型分析PCOS患者不孕的影响因素，并进一步分析1, 25-二羟维生素D31, 25-(OH)2D3、ox-LDL与PCOS患者不孕的关系以及二者对PCOS患者不孕的交互作用，采用限制性立方样条模型分析1, 25-(OH)2D3、ox-LDL与PCOS患者不孕的非线性关系。
    结果 150例PCOS患者中, 78例未妊娠，不孕发生率为52.00%(78/150)。多因素Logistic回归分析显示, PCOS病情程度、体质量指数、年龄、1, 25-(OH)2D3、ox-LDL均为PCOS患者不孕的独立影响因素(P < 0.05); 调整混杂因素后, 1, 25-(OH)2D3、ox-LDL仍与PCOS患者不孕风险相关(P < 0.05)。限制性立方样条模型分析显示, 1, 25-(OH)2D3、ox-LDL均与PCOS患者不孕风险呈非线性关系(P < 0.05); 当血清1, 25-(OH)2D3水平 < 35.70 mmol/L时，其与PCOS患者不孕风险呈负相关(P < 0.05); 当血清ox-LDL水平≥381.00 μg/L时，其与PCOS患者不孕风险呈正相关(P < 0.05)。交互作用分析显示, 1, 25-(OH)2D3与ox-LDL对PCOS患者不孕存在拮抗作用(P < 0.05)。
    结论 PCOS患者血清1, 25-(OH)2D3水平降低、ox-LDL水平升高均可显著增加其不孕风险，且二者间存在非线性剂量-效应关系及拮抗交互作用，提示调控维生素D与氧化应激水平可能是改善PCOS患者生育结局的重要策略。

     

    Abstract:
    Objective To explore the relationships of vitamin D and oxidized low-density lipoprotein (ox-LDL) with infertility in patients with polycystic ovary syndrome (PCOS) based on restricted cubic spline models.
    Methods A total of 150 PCOS patients were selected as the study subjects and followed up for at least 1 year. They were divided into infertile group and non-infertile group according to whether they were infertile. A Logistic regression model was used to analyze the influencing factors of infertility in PCOS patients. Furthermore, the relationships of 1, 25-dihydroxyvitamin D31, 25-(OH)2D3 and ox-LDL with infertility in PCOS patients, as well as their interactive effects on infertility in PCOS patients were analyzed. A restricted cubic spline model was used to analyze the non-linear relationships between 1, 25-(OH)2D3, ox-LDL, and infertility in PCOS patients.
    Results Among 150 PCOS patients, 78 were not pregnant, resulting in an infertility rate of 52.00%(78/150). Multivariate Logistic regression analysis showed that the severity of PCOS, body mass index, age, 1, 25-(OH)2D3, and ox-LDL were all independent influencing factors for infertility in PCOS patients (P < 0.05). After adjusting for confounding factors, 1, 25-(OH)2D3 and ox-LDL were still associated with the risk of infertility in PCOS patients (P < 0.05). Restricted cubic spline model analysis revealed non-linear relationships between 1, 25-(OH)2D3, ox-LDL, and the risk of infertility in PCOS patients (P < 0.05). When the serum 1, 25-(OH)2D3 level was < 35.70 nmol/L, it was negatively correlated with the risk of infertility in PCOS patients (P < 0.05). When the serum ox-LDL level was ≥381.00 μg/L, it was positively correlated with the risk of infertility in PCOS patients (P < 0.05). Interactive effect analysis showed that 1, 25-(OH)2D3 and ox-LDL had antagonistic effects on infertility in PCOS patients (P < 0.05).
    Conclusion Decreased serum 1, 25-(OH)2D3 levels and increased ox-LDL levels in PCOS patients can significantly increase the risk of infertility. Moreover, there is a non-linear dose-response relationship and an antagonistic interactive effect between them, suggesting that regulating vitamin D and oxidative stress levels may be an important strategy for improving the fertility outcomes of PCOS patients.

     

    • HTML全文
    • 参考文献(28)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回