Objective To evaluate the clinical efficacy and safety of sodium hyaluronate medical dressing for sensitive skin.

Methods A self-controlled before-and-after trial design was adopted. Thirty subjects with sensitive skin were selected as the study cohort, and received intervention with sodium hyaluronate medical dressing. Skin barrier function, self-assessment results of the subjects, and researcher assessment results were compared before and after intervention. Additionally, the occurrence of adverse reactions was observed.

Results All 30 subjects completed the 4-week intervention and follow-up strictly according to the protocol. When comparing the skin water content and transepidermal water loss (TEWL) at the 2nd and 4th weeks of dressing use with those before dressing use, there was no statistically significant difference (P>0.05). The self-assessment results of facial discomfort symptoms in the subjects showed that, compared with before use, the scores for tightness, dryness, desquamation, burning sensation, prickling sensation, itching, redness, erythema, and telangiectasia at the 2nd and 4th weeks of dressing use were all reduced, with statistically significant differences (P < 0.05). The researcher assessment results indicated that the scores for facial erythema severity in the subjects at the 2nd and 4th weeks of dressing use were lower than those before use, with statistically significant differences (P < 0.05). During the study, no relevant adverse reactions occurred.

Conclusion Sodium hyaluronate medical dressing can effectively alleviate the subjective symptoms of patients with sensitive skin and has good safety and tolerability, especially suitable for individuals with mild-to-moderate sensitive skin.