多模态列线图预测乳腺癌淋巴结转移的研究进展

Research progress of multimodal nomograms in predicting lymph node metastasis in breast cancer

  • 摘要: 乳腺癌(BC)是全球女性发病率最高的恶性肿瘤。准确评估淋巴结转移状态对制订个体化综合治疗策略、优化临床决策及预测患者预后具有重要意义。列线图作为一种基于多变量回归分析的可视化预测工具, 能够整合临床病理特征、影像组学参数及基因组学标志物等多维度变量,以量化方式个体化评估BC患者淋巴结转移风险。本文系统综述列线图在BC淋巴结转移预测中的研究进展,重点阐述基于临床特征、影像组学、基因组学等多维度数据构建的列线图模型,评价其应用特点和预测准确性等指标,通过不断完善列线图以构建更适用于临床预测的模型。本文旨在推动列线图的优化与标准化,为BC精准诊疗体系的完善提供循证依据与实践参考。

     

    Abstract: Breast cancer (BC) is the most prevalent malignant tumor among women worldwide. Accurate assessment of lymph node metastasis status is of great significance for formulating individualized comprehensive treatment strategies, optimizing clinical decision-making, and predicting patient prognosis. As a visual predictive tool based on multivariate regression analysis, a nomogram can integrate multidimensional variables such as clinicopathological features, radiomic parameters, and genomic biomarkers to quantitatively evaluate the individual risk of lymph node metastasis in BC patients. This article systematically reviewed the research progress of nomograms in predicting lymph node metastasis, focusing on nomogram models constructed based on multidimensional data including clinical characteristics, radiomics, and genomics. It evaluated their application characteristics and predictive accuracy indicators, aiming to continuously improve nomograms to build models more suitable for clinical prediction. This article aimed to promote the optimization and standardization of nomograms and provide evidence-based and practical references for the improvement of the precise diagnosis and treatment system for BC.

     

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