Abstract: Early, complete, and sustained reperfusion of the culprit vessel is critical for successful rescue and long-term prognostic improvement in patients with acute ST-segment elevation myocardial infarction (STEMI).This report described a patient with STEMI initially presenting with chest pain and found to have three-vessel coronary artery disease during angiography.Rapid identification of the culprit vessel and intraoperative adjustment of the rescue strategy successfully rescued the patient's life and improved prognosis despite of recurrent ventricular fibrillation and electrical storm.