Objective To investigate the therapeutic effect of modified Huangqi Jianzhong Decoction combined with omeprazole sodium in treating gastroduodenal ulcer with spleen-stomach deficiency-cold syndrome.

Methods A total of 150 patients with gastroduodenal ulcer of spleen-stomach deficiency-cold type were selected and randomly divided into observation group and control group using a random number table method, with 75 cases in each group. The control group was treated with omeprazole sodium injection, while the observation group was treated with modified Huangqi Jianzhong Decoction combined with omeprazole sodium. The therapeutic effect was evaluated after 4 weeks of treatment. The endoscopic ulcer healing rate and gastric mucosal function indicators pepsinogen Ⅰ (PGⅠ), pepsinogen Ⅱ (PGⅡ), inflammatory factors tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8) before and after treatment were compared between the two groups. The incidence of adverse reactions was statistically analyzed, and the recurrence of gastroduodenal ulcer during a 6-month follow-up after treatment was recorded.

Results The total effective rate in the observation group was higher than that in the control group, with a statistically significant difference (P < 0.05). The endoscopic ulcer healing rate in the observation group was higher than that in the control group, with a statistically significant difference (P < 0.05). After treatment, the serum PGⅠ levels in both groups increased compared with those before treatment, while the PGⅡ levels decreased. Moreover, the PGⅠ level in the observation group was higher than that in the control group, and the PGⅡ level was lower than that in the control group, with statistically significant differences (P < 0.05). After treatment, the serum TNF-α and IL-8 levels in both groups decreased compared with those before treatment, and were lower in the observation group than those in the control group, with statistically significant differences (P < 0.05). During the treatment period, there was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). During the follow-up period, there was a statistically significant difference in the recurrence rate of gastroduodenal ulcer between the two groups (P < 0.05).

Conclusion Modified Huangqi Jianzhong Decoction combined with omeprazole sodium can improve the therapeutic effect, accelerateulcer healing, regulate gastric mucosal function, reduce inflammation, lower the recurrence rate of ulcer, and has good safety in treating gastroduodenal ulcer with spleen-stomach deficiency-cold syndrome.