Objective To investigate the efficacy of endoscopic-assisted glandular resection with preservation of the nipple-areola complex (NAC) combined with prosthesis+Ti-Loop patch breast reconstruction in the treatment of breast cancer (BC) and its impacts on postoperative complications.

Methods A total of 162 patients undergoing radical mastectomy for BC were selected and randomly divided into control group and study group, with 81 cases in each group. The control group received endoscopic-assisted glandular resection combined with preservation of the NAC and immediate prostheticbreast reconstruction, while the study group received endoscopic-assisted glandular resection with preservation of the NAC combined with prosthesis+Ti-Loop patch breast reconstruction. The operative time, intraoperative blood loss, postoperative drainage time, time to initiation of neoadjuvant chemotherapy, time to first postoperative ambulation, 24-hour postoperative Visual Analogue Scale (VAS) score, hospital stay, and preoperative and postoperative breast aesthetic scores, Self-esteem Scale (SES) scores, General Quality of Life Inventory-74 (GQOLI-74) scores, Self-rating Anxiety Scale (SAS) scores, Self-rating Depression Scale (SDS) scores, as well as postoperative complications, recurrence, metastasis, and survival were compared between the two groups.

Results The operative time in the study group was longer than that in the control group, but the time to first postoperative ambulation and hospital stay were shorter, and the 24-hour postoperative VAS score was lower in the study group, with statistically significant differences(P < 0.05). From 1 week to 6 months postoperatively, the breast aesthetic scores of BC patients in the study group were higher than those in the control group. At 6 months postoperatively, the SES scores and GQOLI-74 scores in the study group were higher than those in the control group, while the SAS scores and SDS scores were lower; the incidences of subcutaneous effusion, incision necrosis, upper limb edema, and nipple necrosis in the study group were lower than those in the control group, with statistically significant differences (P < 0.05). During the postoperative follow-up period, there were no statistically significant differences in the local tumor recurrence rate, mortality rate, and incidence of distant metastasis between the two groups (P>0.05).

Conclusion Endoscopic-assisted glandular resection with preservation of the NAC combined with prosthesis+Ti-Loop patch breast reconstruction for BC has good surgical efficacy, and can effectively reduce the incidence of postoperative complications, so it is a safe approach.