基于中国人群的声门暴露困难预测模型的前瞻性研究

A prospective study on predictive model for difficult laryngeal exposure based on Chinese population

  • 摘要:
    目的 构建针对中国人群喉显微手术声门暴露困难(DLE)的简化预测模型并评估其临床价值。
    方法 前瞻性纳入2022年1月— 2023年12月接受喉显微手术的384例患者为研究对象, 将Cormack-Lehane Ⅲ~Ⅳ级定义为DLE。采用单因素分析及多元Logistic回归分析筛选独立危险因素,构建包含体质量指数(BMI)≥28 kg/m2、颈围≥40 cm、甲颏距离 < 6.5 cm、改良Mallampati评分Ⅲ~Ⅳ级、颈部活动度中度和重度受限共5个参数的预测模型,采用受试者工作特征(ROC)曲线的曲线下面积(AUC)、Bootstrap法验证预测模型效能。
    结果 模型阴性预测值为95.3%, 区分效能良好(AUC=0.876, 95%CI: 0.835~0.917), 内部验证稳定(校正AUC=0.862); 截断值≥3分时,模型的敏感度为86.0%, 特异度为82.6%。
    结论 该模型可在术前精准识别DLE高风险患者,为个体化手术准备提供参考。

     

    Abstract:
    Objective To construct a simplified predictive model for difficult laryngeal exposure (DLE) during laryngomicrosurgery in Chinese population and evaluate its clinical value.
    Methods A total of 384 patients with laryngomicrosurgery from January 2022 to December 2023 were selected. DLE was defined as Cormack-Lehane grades Ⅲ to Ⅳ. Univariate analysis and multivariate Logistic regression were used to screen independent risk factors. A predictive model was constructed incorporating 5 parameters: body mass index (BMI) ≥28 kg/m2, neck circumference ≥40 cm, thyromental distance < 6.5 cm, modified Mallampati classification grades Ⅲ to Ⅳ, and moderate-to-severe restriction of neck mobility. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve and the Bootstrap method were employed to validate the performance of the model.
    Results The model demonstrated a negative predictive value of 95.3%, good discriminatory performance (AUC=0.876, 95%CI, 0.835 to 0.917), and stable internal validation (adjusted AUC=0.862). When the cut-off value was ≥3 points, the model exhibited a sensitivity of 86.0% and a specificity of 82.6%.
    Conclusion This model can accurately identify patients at high risk of DLE before surgery, providing a reference for individualized surgical preparation.

     

/

返回文章
返回