Abstract: Cutaneous squamous cell carcinoma (cSCC) is a commonly encountered malignant skin tumor in clinical practice, with wide surgical excision being the standard treatment. However, large or structurally complex wounds often remain after surgery, posing high demands on repair strategies. Traditional repair methods such as autologous skin grafting or flap transplantation, although widely used, have limitations including donor site injury and suboptimal aesthetic outcomes. Tissue-engineered skin (TES), as a bioactive substitute, simulates the structure of natural skin and offers advantages such as promoting re-epithelialization, reducing scar formation, minimizing donor site injury, and optimizing appearance and functional recovery, providing an innovative solution for wound repair after cSCC surgery. This article systematically reviewed current application status of TES in wound management after cSCC surgery and integrates its mechanisms of action in wound healing, immune regulation, and barrier function reconstruction, aiming to provide theoretical support and translational directions for promoting high-quality, individualized wound repair after cSCC surgery.