Diagnostic value of cervical biopsy under colposcope and pathological examination after loop electrosurgical excision procedure on cervical intraepithelial neoplasia

Objective To investigate the diagnostic value of cervical biopsy under colposcope and pathological examination after loop electrosurgical excision procedure (LEEP)on cervical in-traepithelial neoplasia (CIN).Methods A total of 380 patients,with abnormal detection of thin-prip cytologic test (TCT)and /or human papillomavirus (HPV)or with macroscopic moderate and severe exstrophy of cervical columnar epithelium even if TCT and /or HPV were normal,were given cervical biopsy under colposcope and LEEP.The diagnostic accordance rate of two detection meth-ods was compared.Results The total diagnostic accordance rate of two group was 65.00% (247-380),in which the rates of patients diagnosed with CINⅠand CIN Ⅱ /Ⅲ combined with carcinoma in situ by cervical biopsy under colposcope but with CIN Ⅱ /Ⅲ and carcinoma with micro-infiltra-tion under LEEP were 10.59% (9 /85)and 11.40% (13 /114),respectively.Compared with the terminal pathological results of combined detection,the total diagnostic accordance rates of cervical biopsy under colposcope and LEEP were 80.79% (307 /380)and 84.21% (320 /380),respective-ly.Conclusion Cervical biopsy under colposcope can effectively diagnose CIN but with the slight risk of misdiagnosing micro-infiltration,and its combination with LEEP can apparently improve diagnostic accuracy.