Influence of low calcium dialysate calcium on calcium and phosphorus metabolism and parathyroid hormone in patients with maintenance hemodialysis

Objective To explore the effect of low calcium dialysate on calcium and phosphorus metabolism and parathyroid hormone in patients with maintenance hemodialysis.Methods A total of 60 non-hypocalcemia patients with maintenance hemodialysis were randomly divided into observation group and control group.The observation group was treated with low calcium dialysate (Ca2 + concentration was 1.25 mmol/L),while the control group was treated with conventional calcium dialysate (Ca2 + concentration was 1.50 mmol/L).Effect was compared between two groups.Results After treatment,the serum T-Ca,T-Ca × P significantly decreased in the observation group,and serum iPTH significantly increased (P ＜ 0.05).In the control group,the serum T-Ca,T-Ca x P significantly increased,and serum iPTH decreased significantly (P ＜ 0.05).The serum levels of TCa,T-Ca x P in the observation group were significantly lower than those in the control group,and the serum iPTH level was significantly higher than that in the control group (P ＜ 0.05).After 6 months of treatment,the serum hs-CRP level of the observation group was significantly lower than that of the control group (P ＜ 0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups (P ＞ 0.05).Conclusion Application of low calcium dialysate can decrease serum high calcium loading,improve the status of excessive inhibition of parathyroid hormone and cardiovascular inflammation status in treatment of non-hypocalcemia patients with maintenance hemodialysis.