Clinical study on statin therapy and dose selection in treatment of patients with acute coronary syndrome in acute stage

Objective To explore the statin therapy and dose selection in treatment of patients with acute coronary syndrome in acute stage.Methods A total of 120 patients with acute coronary syndrome in acute stage were selected and randomly divided into the group A (atorvastatin 20 mg),group B (atorvastatin 10 mg) and group C (routine treatment).The effect was compared.Results After treatment,the levels of total cholesterol (TC),triglyceride (TG),low density lipoprotein cholesterol (LDL-L),and high sensitive C reactive protein (hs-CRP) significantly improved in the group A and group B (P ＜ 0.05).After 4 weeks and 8 weeks of treatment,the levels of TC,TG,LDL-C in group A were significantly lower than the other two groups (P ＜ 0.05),the hs-CRP was significantly lower than the other two groups (P ＜ 0.05),and the TC,LDL-C standard rate were significantly better than the other two groups (P ＜ 0.05).There was no significant difference in the incidence rate of adverse reactions between the group A and group B.After 8 months of follow up,the incidence rate of cardiovascular events in group A was significantly lower than the other two groups (P ＜ 0.05).Conclusion Early use of large doses of atorvastatin is effective in treatment of patients with acute coronary syndrome in acute stage,and it can achieve the anti-inflammatory and lipid lowering effects,and reduce the incidence rate of cardiovascular events.