Objective To explore the effect of medical polyethylene glycol berberine on clinical outcomes after curettage.
Methods A total of 166 curettage patients were divided into study group (n=80) and control group (n=86) by the patients′ willingness. The two groups were given routine curettage, and the study group were additionally given 3 mL medical polyethylene glycol berberine by uterine cavity injection, while the control group infused no drugs. The postoperative endometrial thickness, menstruation situation were compared, and the re-pregnancy conditions of the patients in control group (n=20) and experimental group (n=32) with two-child requirement at follow-up and in one and a half year after follow-up were compared.
Results The endometrial thickness in the study group was thicker than that in the control group (9.44±1.95) mm vs. (8.65±2.28) mm, P < 0.05, the proportion of the endometrial thickness < 8 mm in the study group was lower than that in the control group27.5%(22/80) vs. 38.4%(33/8), P < 0.01. The ratio of patients with eumenorrhea was lower than that in the control group(10%(8/80) vs. 16.3%(14/86), but there was no significant difference(P>0.05). The clinical pregnancy rate of the patients who had pregnancy requirements in the control group was higher than that in the control group 93.75%(30/32) vs. 70%(14/20), P < 0.05.
Conclusion Medical polyethylene glycol berberine can promote the pregnancy rate. Meanwhile, the operation is simple and has higher compliance rate, which is an effective way in improving clinical outcomes.
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