Relationship between expression of interleukin in serum as well as gastric juice of patients with peptic ulcer bleeding and Helicobacter pylori infection

Objective To investigate the relationship between the expression of interleukin in serum as well as gastric juice and Helicobacter pylori infection in patients with peptic ulcer hemorrhage. Methods A total of 320 patients with peptic ulcer were selected as the research objects and divided into ulcer group(n=60)and ulcer bleeding group(n=260). In addition, 50 patients diagnosed as common superficial ulcer in physical examination during the same period were selected as control group. The levels of interleukin-6(IL-6)and interleukin-8(IL-8)in serum and gastric juice of patients in the three groups were compared, and the levels of IL-6 and IL-8 in serum and gastric juice of Helicobacter pylori positive andnegative patients in the ulcer bleeding group were compared. Results The levels of serum IL-6, IL-8, gastric juice IL-6 and IL-8 in the ulcer bleeding group were significantly higher than those in the ulcer group and the control group(P<0.05). The levels of IL-6 and IL-8 in serum and gastric juice in the ulcer group were significantly higher than those in the control group(P<0.05). In the ulcer bleeding group, the number of Helicobacter pylori positive cases was 115(44.23%), while the number of Helicobacter pylori negative cases was 145(55.77%). The levels of serum IL-6, IL-8, gastric juice IL-6 and IL-8 in patients with Helicobacter pylori positive in the ulcer bleeding group were significantly higher than those of Helicobacter pylori negative ones(P<0.05). Conclusion The levels of serum IL-6, IL-8, gastric juice IL-6 and IL-8 are highly expressed - in patients with peptic ulcer bleeding and their levels are closely related to the pathogenesis of peptic ulcer bleeding and Helicobacter pylori infection.