Research of preparation of injectable phycocyanin nanocomposite hydrogels and its application effect in wound healing

Objective To investigate the effect of preparation of shear-thinning CPC/LP nanocomposite hydrogel for wound healing by supramolecular interaction of polydopamine (LP) and phycocyanin (CPC) based on nano-clayoxidation.

Methods LP aggregates were formed by polymerization of dopamine monomers in weak alkaline oxygen-containing environment of nano-clay dispersion, and then mixed it with multifunctional CPC to form shear-thinning nanocomposite hydrogels by electrostatic action and Schiff base. The microstructure, rheological properties, blood compatibility and wound healing effect of hydrogel were studied systematically.

Results The gelation performance of CPC/LP nanocomposite hydrogel was related to LP content. When LP content was 3% and CPC content was 0.5%, stable gel could be formed; rheological test results showed that the nanocomposite hydrogel had the properties of shear thinning and self-healing; the results of blood compatibility test showed that the hemolysis rate of the nanocomposite hydrogel was less than 5%, and it had good blood compatibility. In addition, the nanocomposite hydrogel could be injected into the injury site through a smaller needle to promote wound healing.

Conclusion CPC/LP nanocomposite hydrogel exhibits excellent injectable properties and can effectively promote wound healing.