Research progress on molecular mechanisms and precise interventions for long respiratory sequelae of Coronavirus Disease 2019

As an acute respiratory infectious disease, the global spread of Coronavirus Disease 2019(COVID-19) has had tremendous impacts on public health. After the acute infection phase, a considerable proportion of infected individuals still experience various symptoms that may persist for weeks to months, or even longer, a condition known as long COVID-19 syndrome. Long-term COVID-19 syndrome exhibits diverse clinical manifestations, with common symptoms in the respiratory system including persistent cough, dyspnea, chest pain, and decreased lung function, which can significantly affect patients' quality of life. This review summarized the common clinical manifestations, pathogenesis, and advances in diagnosis and treatment of long COVID-19 syndrome in the respiratory system, aiming to enhance awareness of respiratory complications associated with long COVID-19, thereby facilitating more rational responses and the provision of evidence-based strategies for symptom management and pulmonary rehabilitation.