Influence of different blood collection sites on coagulation during systemic heparin anticoagulation period treated by continuous renal replacement therapy

Objective To investigate the impact of blood sampling from different sites on coagulation results during systemic heparin anticoagulation period treated by continuous renal replacement therapy (CRRT).

Methods Seventy-eight patients undergoing CRRT with systemic heparin anticoagulation were selected. Using a self-control method, blood samples were simultaneously collected from sampling port at input end of the CRRT extracorporeal circuit, the arterial pressure monitoring catheter, and the peripheral vein of the patients. The four coagulation parameters were tested, and the differences in coagulation results among the blood sampling sites were compared.

Results During CRRT with systemic heparin anticoagulation, the four coagulation parameters using blood samples collected from the sampling port at the input end of the CRRT extracorporeal circuit, the arterial pressure monitoring catheter, and the peripheral vein showed no statistically significant differences (P>0.05). Subgroup analyses based on different hemofiltration machines and heparin doses also showed no statistically significant differences (P>0.05).

Conclusion During CRRT, blood sampling from the sampling port at the input end of the circuit or the arterial pressure monitoring catheter can be used as an alternative to peripheral venous blood sampling, with no impact on coagulation results.