Clinical efficacy of Ginkgo Diterpene Lactone Meglumine Injection combined with alteplase in treatment of acute ischemic stroke with large vessel occlusion

Objective To observe the clinical efficacy of Ginkgo Diterpene Lactone Meglumine Injection combined with alteplase (rt-PA) in the treatment of acute ischemic stroke with large vessel occlusion.

Methods A total of 170 patients with acute ischemic stroke with large vessel occlusion were selected as the study subjects and randomly divided into control group (receiving intravenous rt-PA thrombolytic therapy) and observation group (receiving Ginkgo Diterpene Lactone Meglumine Injection in addition to the treatment in the control group), with 85 cases in each group. Serological indicatorsneuron-specific enolase (NSE), vascular endothelial growth factor (VEGF), homocysteine (Hcy), high-sensitivity C-reactive protein (hs-CRP), matrix metalloproteinase-9 (MMP-9), cerebral blood flow velocity in the middle cerebral arteryend-diastolic velocity (EDV), peak systolic velocity (PSV), mean velocity (Vm), neurological functionNational Institutes of Health Stroke Scale (NIHSS) score, cognitive functionMini-mental State Examination (MMSE) score, modified Rankin Scale (mRS) score, and the incidence of complications were compared between the two groups.

Results After treatment, the serum levels of NSE, Hcy, hs-CRP, MMP-9, and the NIHSS and mRS scores in both groups were lower than those before treatment, while the serum level of VEGF and the MMSE score were higher than those before treatment(P < 0.05). Moreover, the serum levels of NSE, Hcy, hs-CRP, MMP-9, and the NIHSS and mRS scores in the observation group were lower than those in the control group, and the serum level of VEGF and the MMSE score were higher than those in the control group, with statistically significant differences (P < 0.05). After treatment, the EDV, PSV and Vm in both groups were higher than those before treatment, and those in the observation group were higher than those in the control group, with statistically significant differences (P < 0.05). There was no statistically significant difference in the overall incidence of complications between the two groups (P>0.05).

Conclusion Ginkgo Diterpene Lactone Meglumine Injection combined with rt-PA can effectively improve the neurological and cognitive functions of acute ischemic stroke patients with large vessel occlusion.