Effects of nimodipine combined with mild hypothermia therapy on cognitive function and collateral circulation in patients with acute ischemic stroke

Objective To investigate the effects of nimodipine tablets combined with mild hypothermia therapy on cognitive function and collateral circulation in patients with acute ischemic stroke.

Methods A total of 100 patients with acute ischemic stroke were selected as the study subjects and randomly divided into control group (treated with mild hypothermia therapy, n=50) and observation group (treated with nimodipine tablets combined with mild hypothermia therapy, n=50). Neurological function, cognitive function, collateral circulation indicators, serum indicators and safety were compared between the two groups.

Results After treatment, the National Institutes of Health Stroke Scale (NIHSS) scores of patients in both groups were significantly lower than those before treatment, while the Montreal Cognitive Assessment (MoCA) scores were significantly higher than those before treatment (P < 0.05). After treatment, the NIHSS scores of patients in the observation group were significantly lower than those in the control group, while the MoCA scores were significantly higher than those in the control group (P < 0.05). After treatment, the collateral circulation indicators of patients in both groupswere significantly higher than those before treatment, and those in the observation group weresignificantly higher than those in the control group (P < 0.05). After treatment, the levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP), intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) in patients in both groups were significantly lower than those before treatment, and the observation group was significantly lower than the control group (P < 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05).

Conclusion Nimodipine tablets combined with mild hypothermia therapy can effectively improve neurological and cognitive functions, promote the establishment of collateral circulation, increase cerebral blood flow velocity, and exhibit good safety in patients with acute ischemic stroke.