非洛地平对高血压患者动脉粥样硬化和血管内皮功能的影响

周磊; 温国明; 郭民法; 黄霞; 何万红; 宁景春; 张春蓉

doi:10.3969/j.issn.1672-2353.2006.05.011

非洛地平对高血压患者动脉粥样硬化和血管内皮功能的影响

1.
广东省深圳市龙华人民医院,心内科,广东,深圳,518109;
2.
广东省深圳市龙华人民医院,心脏超声科,广东,深圳,518109

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- 发布日期: 2006-07-06

EFFECTS OF FELODIPINE ON ENDOTHELIAL FUNCTION AND ATHEROSCLEROSIS PROGRESSION OF LARGE ARTERIES IN HYPERTENSIVE PATIENTS

摘要

摘要: 目的探讨非洛地平对高血压病患者颈动脉粥样硬化和内皮功能的影响.方法将高血压病患者随机分为A组n=35(非洛地平治疗组)和B组n=35(福辛普利治疗组),另设年龄、性别与之匹配的正常人为C组n=30(对照组).用高分辨超声技术检测各组对象的肱动脉内皮依赖性舒张功能、颈动脉平均内中膜厚度、颈动脉斑块发生率及Croouse积分.对A、B组分别在治疗3个月、1年及2年后复查血压和血管超声的上述指标.结果与C组比较,A组与B组肱动脉内皮依赖性舒张功能减退,颈动脉内中膜增厚(P＜0.01).非洛地平组与福辛普利组在降低血压及改善血管内皮依赖性舒张功能方面作用相同(P＞0.05),但非洛地平组在逆转颈动脉内中膜厚度、降低新的粥样斑块发生率方面优于福辛普利组(P＜0.01).结论非洛地平除能有效降低高血压患者的血压外,还有逆转大动脉功能和结构异常,延缓动脉粥样硬化发生发展的作用.
- 钙通道阻滞剂 /
- 高血压 /
- 动脉

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文章访问数: 144
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非洛地平对高血压患者动脉粥样硬化和血管内皮功能的影响

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EFFECTS OF FELODIPINE ON ENDOTHELIAL FUNCTION AND ATHEROSCLEROSIS PROGRESSION OF LARGE ARTERIES IN HYPERTENSIVE PATIENTS

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