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摘要: 目的 研究厄贝沙坦对急性心肌梗死患者血清超敏c反应蛋白(hs-CRP)含量的影响.方法 将60例急性心肌梗死患者随机分为厄贝沙坦组(30例)和常规治疗组(30例),并以30例非心血管病患者作为对照组.厄贝沙坦组给予厄贝沙坦150 mg、阿司匹林150 mg,1次/d;常规治疗组给予阿司匹林150 mg,1次/d;2组其余治疗方法 相同,连续治疗14 d.在治疗前、治疗14 d抽取静脉血,用比浊法检测血清hs-CRP含量,并对无创心功能(心脏射血分数EF%)进行评定.结果 2组心肌梗死患者血清hs-CRP含量较对照组显著升高(P<0.01).厄贝沙坦组和常规治疗组治疗后血清hs-CRP含量较治疗前有显著降低(均P<0.01)和EF较治疗前有显著增加(P<0.01).厄贝沙坦组治疗前后血清hs-CRP含量的差值显著大于常规治疗组(P<0.05).结论 厄贝沙坦能明显降低急性心肌梗死患者的血清hs-CRP水平,并有助于心肌梗死患者的心功能恢复.
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