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快速心室起搏犬心房颤动模型研究

许铭, 王欣, 唐闽, 宁小辉, 柳磊, 王巍, 王立清, 宋云虎

许铭, 王欣, 唐闽, 宁小辉, 柳磊, 王巍, 王立清, 宋云虎. 快速心室起搏犬心房颤动模型研究[J]. 实用临床医药杂志, 2011, (3): 1-5,10. DOI: 10.3969/j.issn.1672-2353.2011.03.001
引用本文: 许铭, 王欣, 唐闽, 宁小辉, 柳磊, 王巍, 王立清, 宋云虎. 快速心室起搏犬心房颤动模型研究[J]. 实用临床医药杂志, 2011, (3): 1-5,10. DOI: 10.3969/j.issn.1672-2353.2011.03.001
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Study on the canine model of atrial fibrillation with ventricular tachypacing-induced heart failure[J]. Journal of Clinical Medicine in Practice, 2011, (3): 1-5,10. DOI: 10.3969/j.issn.1672-2353.2011.03.001
Citation: Study on the canine model of atrial fibrillation with ventricular tachypacing-induced heart failure[J]. Journal of Clinical Medicine in Practice, 2011, (3): 1-5,10. DOI: 10.3969/j.issn.1672-2353.2011.03.001
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快速心室起搏犬心房颤动模型研究

  • 北京协和医学院,中国医学科学院,阜外心血病医院,心血管病研究所,北京,100037

基金项目: 国家自然科学基金资助项目
详细信息

  • 中图分类号: R541.6

Study on the canine model of atrial fibrillation with ventricular tachypacing-induced heart failure

摘要

    摘要
  • 摘要: 目的 建立快速起搏心室致心力衰竭犬房颤模型,研究其电生理及心房结构和功能改变.方法 15只健康杂种犬分两组:对照组6只,实验组9只[240次/min心室起搏(25±3) d].超声心动图测定起搏前后心房面积、面积缩小分数及左心室功能,利用心内电极测定心房有效不应期、传导速度及房颤诱发情况.结果 实验组7只犬完成了实验.快速心室起搏(25±3) d后,犬的收缩末期和舒张末期左、右心房面积显著增大(与起搏前比较, P<0.01), 左、右心房面积缩小分数显著减小(左心房: (35.7±1.9)%和(20.7±2.7)%, P<0.01; 右心房: (35.0±2.3)%和(18.0±2.3)%, P<0.01), 左室射血分数从(65.3±2.1)%降至(31.6±2.8)%(P<0.01).实验组犬左、右心房有效不应期显著延长,心房内传导速率较对照组减慢.实验组有5只犬诱发出超过30 min的房颤,平均房颤持续时间较对照组显著延长(687±290) s和(13±9) s, P<0.01).实验组平均房颤持续时间与左、右心房面积及面积缩小分数相关(P<0.05).结论 快速心室起搏致心衰模型能稳定地诱发出房颤,房颤持续时间与心衰引起的显著心房结构和功能异常相关.
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    • 参考文献(13)
  • Camm A J, Kirchhof P, Lip G Y. Guidelines for the management of atrial fibrillation:the task force for the management of atrial fibrillation of the european society of cardiology (ESC) [J]. Europace:European Pacing, Arrhythmias and Cardiac Electrophysiology, 2010, (10):1360.
    Stambler B S. Characterization of sustained atrial tachycardia in dogs with rapid ventricular pacing-induced heart failure [J]. Journal of Cardiovascular Electrophysiology, 2003(5):499.doi: 10.1046/j.1540-8167.2003.02519.x.
    Nishida K, Michael G, Dobrev D. Animal models for atrial fibrillation:clinical insights and scientific opportunities [J]. Europace:European Pacing, Arrhythmias and Cardiac Electrophysiology, 2010(2):160.
    Li D, Fareh S, Leung T K. Promotion of atrial fibrillation by heart failure in dogs:atrial remodeling of a different sort [J]. Circulation, 1999(1):87.
    Cha T J, Ehrlich J R, Zhang L. Dissociation between ionic remodeling and ability to sustain atrial fibrillation during recovery from experimental congestive heart failure [J]. Circulation, 2004(3):412.doi: 10.1161/01.CIR.0000109501.47603.0C.
    Yang S S, Han W, Zhou H Y. Effects of spironolactone on electrical and structural remodeling of atrium in congestive heart failure dogs [J]. Chinese Medical Journal, 2008(1):38.
    Schuessler R B, Kawamoto T, Hand D E. Simultaneous epicardial and endocardial activation sequence mapping in the isolated canine right atrium [J]. Circulation, 1993(1):250.
    Derakhchan K, Li D, Courtemanche M. Method for simultaneous epicardial and endocardial mapping of in vivo canine heart:application to atrial conduction properties and arrhythmia mechanisms [J]. Journal of Cardiovascular Electrophysiology, 2001(5):548.doi: 10.1046/j.1540-8167.2001.00548.x.
    Tang M, Zhang S, Sun Q. Effect of nifekalant on acute electrical remodelling in rapid atrial pacing canine model [J]. Chinese Medical Journal, 2006, (24):2056.
    Verhorst P M, Kamp O, Welling R C. Transesophageal echocardiographic predictors for maintenance of sinus rhythm after electrical cardioversion of atrial fibrillation [J]. American Journal of Cardiology, 1997, (10):1355.doi: 10.1016/S0002-9149(97)00139-2.
    Romano M A, Bach D S, Pagani F D. Atrial reduction plasty Cox maze procedure:extended indications for atrial fibrillation surgery [J]. Annals of Thoracic Surgery, 2004(4):1282.doi: 10.1016/j.athoracsur.2003.06.022.
    Verheule S, Wilson E, Everett T T. Alterations in atrial electrophysiology and tissue structure in a canine model of chronic atrial dilatation due to mitral regurgitation [J]. Circulation, 2003, (20):2615.
    Aldhoon B, Melenovsky V, Peichl P. New insights into mechanisms of atrial fibrillation [J]. Physiological Research, 2010(1):1.
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出版历程
  • 发布日期:  2011-05-03

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