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CCND1基因G870A多态性与肺癌危险性的Meta分析

朱陵君, 朱全, 张锦英, 刘连科, 郭人花, 李俊, 束永前

朱陵君, 朱全, 张锦英, 刘连科, 郭人花, 李俊, 束永前. CCND1基因G870A多态性与肺癌危险性的Meta分析[J]. 实用临床医药杂志, 2011, (3): 18-20,23. DOI: 10.3969/j.issn.1672-2353.2011.03.005
引用本文: 朱陵君, 朱全, 张锦英, 刘连科, 郭人花, 李俊, 束永前. CCND1基因G870A多态性与肺癌危险性的Meta分析[J]. 实用临床医药杂志, 2011, (3): 18-20,23. DOI: 10.3969/j.issn.1672-2353.2011.03.005
shu
ZHU Ling-jun, ZHU Qun, ZHANG Jin-ying, LIU Lian-ke, GUO Ren-hua, LI Jun, SHU Yong-qian. The association study between the CCND1 G870A polymorphism and the risk of lung cancer: a meta-analysis[J]. Journal of Clinical Medicine in Practice, 2011, (3): 18-20,23. DOI: 10.3969/j.issn.1672-2353.2011.03.005
Citation: ZHU Ling-jun, ZHU Qun, ZHANG Jin-ying, LIU Lian-ke, GUO Ren-hua, LI Jun, SHU Yong-qian. The association study between the CCND1 G870A polymorphism and the risk of lung cancer: a meta-analysis[J]. Journal of Clinical Medicine in Practice, 2011, (3): 18-20,23. DOI: 10.3969/j.issn.1672-2353.2011.03.005
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CCND1基因G870A多态性与肺癌危险性的Meta分析

  • 江苏省南京医科大学第一附属医院,江苏,南京,210029

基金项目: 江苏省博士后基金资助项目(2010)
详细信息

  • 中图分类号: R734.2

The association study between the CCND1 G870A polymorphism and the risk of lung cancer: a meta-analysis

摘要

    摘要
  • 摘要: 目的 研究细胞周期素D1(Cyclin D1, CCND1)基因G870A多态性与肺癌(Lung cancer)危险性的关系.方法 检索中国医学文献数据库和PubMed, 获取所有关于CCND1基因G870A与肺癌危险性的病例-对照研究,使用Meta分析方法合并G870A与肺癌危险性关系的OR值.同时进行异质性分析、亚组分析和发表偏倚检验.采用固定效应模型和随机效应模型进行分析.结果 纳入符合标准的文献有8篇,共包括4 747例病例和4 512例对照,在显性模型下,G870A多态性能够增加罹患肺癌的风险(OR=1.12, 95%CI=1.02～1.23).种族分层分析发现,此危险在高加索人群中更为显著,而在亚洲人群中并未显著.结论 CCND1基因G870A多态性是肺癌的易感性位点,而且在高加索人群中更为显著.
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  • 发布日期:  2011-05-03

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