抑癌基因BRCA1与紫杉醇耐药关系的研究进展

叶维, 姜维美

叶维, 姜维美. 抑癌基因BRCA1与紫杉醇耐药关系的研究进展[J]. 实用临床医药杂志, 2013, (1): 110-111,114. DOI: 10.7619/jcmp.201301037
引用本文: 叶维, 姜维美. 抑癌基因BRCA1与紫杉醇耐药关系的研究进展[J]. 实用临床医药杂志, 2013, (1): 110-111,114. DOI: 10.7619/jcmp.201301037

抑癌基因BRCA1与紫杉醇耐药关系的研究进展

详细信息
  • 中图分类号: R730.5

  • 摘要: 紫杉醇是目前恶性肿瘤治疗最有效的化疗药物之一,是以微管为作用靶点的肿瘤化疗药物.自美国食物药品管理局(FDA) 1992年批准紫杉醇和1998年批准其半合成的类似物多西紫杉醇上市后,紫杉类药物的临床适应证不断扩展,逐渐成为治疗卵巢癌、乳腺癌、非小细胞肺癌等多种肿瘤的一线用药.紫杉类药物杀死肿瘤细胞不仅依赖于促进微管的聚合,抑制微管解聚,诱导细胞分裂停滞于G2/M期导致细胞凋亡,还可通过其他的信号传导通路直接诱发肿瘤细胞凋亡。
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  • 被引次数: 11
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  • 发布日期:  2013-05-01

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