早期使用鼻塞持续气道正压通气治疗新生儿呼吸窘迫综合征的疗效观察

朱莹雯; 丁晓春; 朱雪萍; 汪清

doi:10.7619/jcmp.201307016

早期使用鼻塞持续气道正压通气治疗新生儿呼吸窘迫综合征的疗效观察

苏州大学附属儿童医院新生儿科,江苏苏州,215003

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中图分类号: R722.12
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- 发布日期: 2013-06-12

Clinical observation of early use of nasal CPAP on neonatal respiratory distress syndrome

摘要

摘要: 目的探讨早期使用鼻塞持续气道正压通气(nCPAP)治疗极低出生体质量患儿呼吸窘迫综合征(RDS)的疗效.方法回顾性分析99例确诊为RDS的极低出生体质量患儿的临床资料.其中,出生后2h内即开始nCPAP辅助呼吸的40例设为治疗组,出生后2h内未使用nCPAP辅助呼吸的59例设为对照组.比较2组患儿的病死率、血气及胸片变化、氧疗、并发症、住院时间、恢复出生体质量时间等指标.结果治疗组病死率为7 5％,对照组为23.3％ (P＜0.05)；治疗组治疗2h后血气指标改善较对照组明显,差异有统计学意义(P＜0.05)；治疗24、48 h后2组血气情况均有改善.在治愈的患儿中,治疗组和对照组机械通气比例分别为37.1％、64.9％ (P＜0.05)；机械通气时间分别为(2.46±2.11)d和(6.79±2.86)d(P＜0.01)；总氧疗时间治疗组为(17.41±13.89)d,对照组为(28.94±12.38) d(P＜0.01)；治疗组和对照组住院天数分别为(40.49±10.45)d和(51.73±15.04)d(P＜0.01)；恢复出生体质量时间分别为(9.71±4.818)d和(13.30±4.807)d(P＜0.01)；支气管肺发育不良发生率分别为8.6％和29.7％ (P＜0.05).结论对于极低出生体质量患儿合并RDS,早期使用nCPAP可明显降低病死率,改善近期预后,疗效安全可靠.
- 鼻塞持续气道正压通气 /
- 新生儿呼吸窘迫综合征 /
- 极低出生体质量患儿

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参考文献(15)

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早期使用鼻塞持续气道正压通气治疗新生儿呼吸窘迫综合征的疗效观察

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Clinical observation of early use of nasal CPAP on neonatal respiratory distress syndrome

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