2型糖尿病患者血清网膜素与糖脂代谢的关系

董慧; 田坚

doi:10.7619/jcmp.201314030

2型糖尿病患者血清网膜素与糖脂代谢的关系

董慧,
田坚

沈阳医学院奉天医院内分泌科,辽宁沈阳,110024

详细信息

中图分类号: R587.1
计量
- 文章访问数: 172
- HTML全文浏览量: 17
- PDF下载量: 5
出版历程
- 发布日期: 2013-10-14

Relationship between serum omentin and glycolipid metabolism in type 2 diabetic patients

DONG Hui,
TIAN Jian

摘要

摘要: 目的探讨2型糖尿病(T2DM)患者血清网膜素与体脂参数、糖脂代谢、胰岛素抵抗及内脂素的相关性.方法选取2012年10-12月本院新诊断的T2DM患者45例,另选取同期体检健康者28例.采用ELISA法检测空腹血清网膜素-1与内脂素水平,同时检测空腹血糖(FPG)、口服葡萄糖耐量试验2h血糖(2h PG)、糖化血红蛋白(HbA1c)、血脂等各项指标及空腹胰岛素(FINS)水平,计算体质量指数(BMI)、腰臀比值(WHR)、胰岛素抵抗指数(HOMA-IR),并分析网膜素-1与各指标之间的关系.结果与对照组相比,糖尿病组血清网膜素-1水平明显降低[(68.6±11.27) μg/L∶(29.8±5.19)μg/L,P＜0.05],内脂素水平明显升高[(9.37±0.85) μg/L∶ (18.67±7.98) μg/L,P＜0.05],血清网膜素-1水平与WHR、HOMA-IR、甘油三酯、2hPG、内脂素均呈负相关(r分别为-0.31,-0.29,-0.46,-0.376,-0.040,P＜0.05).结论血清网膜素-1水平与糖脂代谢相关,可能在糖尿病的发生发展中起一定作用.
- 糖尿病 /
- 网膜素 /
- 内脂素 /
- 糖脂代谢
- diabetes mellitus /
- omentin /
- visfatin /
- glycolipid metabolism

HTML全文

参考文献(10)

Yang R Z, Lee M J, Hu H. Identification of omentin as a novel depot-specific adipokine in human adipose tissue:possible role in rnadulating insulin action [J]. American Journal of Physiology Endocrinology and Metabolism, 2006.E1253.

Fukuhara A, Matsuda M, Nishizawa M. Visfatin:a protein secreted by visceral fat that mimics the effects of insulin [J]. Science, 2005, (5708):426.

Winkler G, Cseh K. Molecular mechanisms of insulin resistance in obesity and type 2 diabetes mellitus [J]. Orvosi Hetilap, 2009, (17):771.

Kraliseh S, Klein J, Bluher M, el al. Therapeutic perspectives of adipocytokines [J]. Expert Opin Phammeother, 2005.863.

Rajala MW, Obiei s, Scherer PE. Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production [J]. Journal of Clinical Investigation, 2003.225.

Okamoto Y, Kihara S, Funahashi T. BAdiponectin:A key adipocytokine in metabolic syndrome [J]. Clinical Science(London), 2006.267.

Liu R, Wang X, Bu P. Omentin-1 is associated with carotid atheroselerosis in patients with metabolic syndrome [J]. Diabetes Research and Clinical Practice, 2011.21.

Shibata R, Takahashi R, Kataoka Y. Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men [J]. Hypertension Research, 2011, (12):1309.

蔡润策, 魏丽, 吴海娅. 肥胖及2型糖尿病患者血清网膜素水平及其相关因素分析 [J]. 中华医学杂志, 2008, (16):1096.doi: 10.3321/j.issn:0376-2491.2008.16.005.

Pan H Y, Guo L, Li Q. Changes of serum omentin-1 levels in normal subjects and in patients with impaired glucose regulation and with newly diagnosed and untreated type 2 diabetes [J]. Diabetes Research and Clinical Practice, 2010(1):29.

施引文献(3)

期刊类型引用(2)

1.	张成岗. 菌粒阴阳学说：基于“人微共生体”探讨中医阴阳学说的学术思考. 中华中医药学刊. 2023(03): 11-20+260 . 百度学术
2.	张成岗. 确保生物安全与发展生物经济的多维思考. 人民论坛·学术前沿. 2022(14): 37-46 . 百度学术

其他类型引用(1)

资源附件(0)

计量

文章访问数: 172
HTML全文浏览量: 17
PDF下载量: 5
被引次数: 3

2型糖尿病患者血清网膜素与糖脂代谢的关系

计量

出版历程

Relationship between serum omentin and glycolipid metabolism in type 2 diabetic patients

期刊类型引用(2)

其他类型引用(1)

计量

出版历程

目录