儿童急性白血病脂联素与血清瘦素的水平及其临床意义

魏德国, 刘艳

魏德国, 刘艳. 儿童急性白血病脂联素与血清瘦素的水平及其临床意义[J]. 实用临床医药杂志, 2014, (3): 130-132. DOI: 10.7619/jcmp.201403046
引用本文: 魏德国, 刘艳. 儿童急性白血病脂联素与血清瘦素的水平及其临床意义[J]. 实用临床医药杂志, 2014, (3): 130-132. DOI: 10.7619/jcmp.201403046
WEI Deguo, LIU Yan. Levels of adiponectin and leptin in children with acute leukemia and their clinical significances[J]. Journal of Clinical Medicine in Practice, 2014, (3): 130-132. DOI: 10.7619/jcmp.201403046
Citation: WEI Deguo, LIU Yan. Levels of adiponectin and leptin in children with acute leukemia and their clinical significances[J]. Journal of Clinical Medicine in Practice, 2014, (3): 130-132. DOI: 10.7619/jcmp.201403046

儿童急性白血病脂联素与血清瘦素的水平及其临床意义

详细信息
  • 中图分类号: R733.71

Levels of adiponectin and leptin in children with acute leukemia and their clinical significances

  • 摘要: 目的 探讨儿童急性淋巴白血病(ALL)血清瘦素、血清脂联素和抵抗素水平的变化及其临床应用价值.方法 选取接受化疗的ALL患儿38例为研究对象,选取同期体检的健康儿童40例为对照组,分别应用ELESA酶联免疫法测定2组清瘦素、血清脂联素和抵抗素水平.结果 与对照组相比,ALL组患儿初诊时血清脂联素显著下降,而血清瘦素、抵抗素水平显著上升,差异有统计学意义(P<0.05).不同化疗效果的患儿,其血清瘦素、血清脂联素和抵抗素水平存在差异,其中CR、PR血清脂联素显著高于NC、PD患儿,而血清瘦素、抵抗素水平显著低于NC、PD患儿,差异有统计学意义(P<0.05).血清瘦素+脂联素+抵抗素联合检测的灵敏性为97.25%,特异性为99.28%,准确性为96.37%显著高于单一检测,差异有统计学意义(P<0.05).结论 血清瘦素、血清脂联素和抵抗素水平的变化与ALL发生有密切的关系,通过测定三者水平能有效预测患者病情的进展及预后.
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  • 发布日期:  2014-05-28

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