联合检测血清 CEA、CA19-9、CA50、CA72-4水平对胃癌的临床诊断价值

Clinical value of combined detection of serum CEA,CA19-9,CA50 and CA72-4 in diagnosis of gastric cancer

摘要: 目的：比较联合检测胃癌患者血清癌胚抗原（CEA）、糖类抗原（CA19-9、CA50、CA72-4）的临床意义。方法分别检测38例胃癌患者（胃癌组）、34例胃炎患者（胃炎组）、37例胃溃疡患者（胃溃疡组）及36例健康者（对照组）血清中 CEA、CA19-9、CA50、CA72-4水平。结果4项标志物检测的灵敏度分别为49．7％（CEA）、54．1％（CA19-9）、38．2％（CA50）、41．7％（CA72-4），联合检测 CEA、CA19-9、CA50、CA72-4灵敏度为79．6％。结论联合检侧 CEA、CA19-9、CA50、CA72-4对胃癌的诊断及疗效观察具有重要临床价值。

Abstract: Objective To compare the clinical significance of combined detection of serum carcino-embryonic antigen (CEA),carbohydrate antigens (CA19-9,CA50 and CA72-4)in the di-agnosis of patients with gastric cancer.Methods The levels of serum CEA,CA19-9,CA50 and CA72-4 in patients with gastric cancer (gastric group,n =38),gastritis (gastritis group,n =34) and gastric ulcer (gastric ulcer group,n =37)as well as healthy people (control group,n =36) were detected respectively.Results The levels of sensitivity of CEA,CA19-9,CA50 and CA72-4 were 49.7%,54.1%,38.2% and 41.7% respectively,while the level of sensitivity of combined detection was 79.6%.Conclusion Combined detection of CEA,CA19-9,CA50 and CA72-4 shows a great clinical significance in the diagnosis and efficacy observation of patients with gastric cancer.