Abstract: Objective To explore the feasibility,safety and efficacy of laparoscopy-assisted radical total gastrectomy(LATG).Methods Clinical materials of LATG patients and open total gas-trectomy (OTG)patients were analyzed retrospectively.Feasibility,safety and short-term outcomes were compared between two groups.Results 274 patients were collected,and there were 109 cases in the LATG group and 165 cases in the OTG group.Operation time in the TLTG group (187.9 ± 37.6)minuteswas significantly longer than that in the OTG group (P <0.001 ),while the intra-operative blood losswassignificantlylowerthan the LATGgroup (1 66 .5 ±5 9 .3 )mL:(3 09 .4 ± 93.1)mL(P <0.001).First flatus time (P <0.001),first diet time (P <0.001),post operative hospital stay (P <0.001),white blood cells counting (P <0.05),and drainage (P <0.05)in the LATG group were significantly lower than those in the OTG group.Conclusion LATG is a safe and feasible procedure for the treatment of gastric cancer,and it has advantages such as high security, small trauma and quick post-operative recovery.