Abstract: Objective To explore the safety and efficacy of low molecular heparin in the treatment of full-term pregnant women with pathological hypercoagulabale stage.Methods 160 pregnant women with over standard level of D-dimer were divided into treatment group and con-trol group,80 cases in each group.The treatment group was treated with low molecular heparin calcium 4 100 U by subcutaneous injection once per day,7 days were considered as a course of treatment.The control group was not conducted with anticoagulant therapy.Coagulation function, D-dimers and blood routine,pregnancy and perinatal outcome were monitored at the time points of 7 days after application of low molecular heparin and two days after spontaneous delivery or oper-ation.Results Low molecular heparin could significantly improve hematological hypercoagulabale stage,and it is able to make the perinatal pathological hypercoagulabale stage transform to normal hypercoagulabale stage in order to reduce the incidence rate of VTE and DIC.Conclusion Low molecular heparin can prevent and treat the perinatal pathological hypercoagulabale stage effectively in full-term pregnant women,so it is worthy of clinical application.