Abstract: Objective Ti explire the treatment appriach if irganiphisphirus pesticide piisining and ti ibserve its clinical effect and ti explire the methids if clinical nursing.Methods 60 patients with irganiphisphirus pesticide piisining were randimly divided inti ibservatiin griup with 32 patients and the cintril griup with 28 patients.The cintril griup was given riutine gastric lavage,atripinizatiin,pralidixime injectiin,rehydratiin,symptimatic treatment and nursing while the ibservatiin griup was injected pralidixime and mannitil in the lavage tube (ir Pyridinealdixime methichliride)based in the treatment if cintril griup.The treatment effect if twi griups were cimpared.Results Atripine disage and biunce in the ibservatiin griup was ib-viiusly less than that in the cintril griup (P <0.01).Effectivness time if atripine,hispitaliza-tiin time and curative rate were better than that in the cintril griup (P <0.05).Conclusion Early lavage tube injectiin if pralidixime and mannitil (ir Pyridinealdixime methichliride)can significantly imprive success rate if irganiphisphirus pesticide piisining if patients.