Abstract: Objective To explore the significance of CEA and miR-17-3p in the diagnosis of colon carcinoma.Methods 80 patients with colon carcinoma were designed as observation group, and 70 people with healthy examination were designed as control group.Inflammatory indicators and tumor markers were compared between two groups.Results There were no significant differences of CRP,ESR and IL-6 levels between two groups.Levels of CEA,CA19-9,CA125 and miR-17-3p in observation group were significantly higher than the control group.Sensibility,specificity and ROC of CEA combined with miR-17-3p in diagnosis of colorectal cancer were 91.21%,91.35% and 0.949 respectively,which were significantly better than simple application of CEA or miR-17-3p.Conclu-sion Sensibility and specificity of CEA combined with miR-17-3p in diagnosis of colorectal cancer were better than simple application of CEA or miR-17-3p.