Abstract: Objective To compared the efficacy of hyaluronan combined with eperisone hy-drochloride or simple application of hyaluronan or eperisone hydrochloride in the treatment of pa-tients with knee osteoarthritis (OA).Methods 99 patients with knee OA were randomly divided into hyaluronan group,eperisone hydrochloride group and combined group (hyaluronan combined with eperisone hydrochloride),33 cases in each group.Efficacy was compared among 3 groups. Rsults 5 weeks after treatment,WOMAC score of combined group was significantly higher than hyaluronan group and eperisone hydrochloride group.The CTX-Ⅱ content of urine in combined group was significantly lower than the other two groups (P <0.05).Conclusion Combination of hyaluronan and eperisone hydrochloride can significantly improve the clinical symptoms of patients with knee OA,and its efficacy is obviously better than simple application of hyaluronan or eperisone hydrochloride.