Efficacy of hyaluronan combined with eperisone hydrochloride in treatment of patients with knee osteoarthritis
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摘要: 目的：对比研究玻璃酸钠联合乙哌立松与单用玻璃酸钠或者单用乙哌立松治疗早中期膝关节骨关节炎的临床疗效。方法门诊选取膝关节骨关节炎患者99例，随机分组，单盲给药，玻璃酸钠治疗组、乙哌立松治疗组和玻璃酸钠结合乙哌立松治疗组各33例，玻璃酸钠结合乙哌立松治疗组予玻璃酸钠关节腔注射及乙哌立松口服治疗，另两组分别单独予玻璃酸钠关节腔注射和乙哌立松口服治疗。比较3组用药后临床症状改善情况及软骨磨损严重程度并作统计学分析。结果经5周治疗后，WOMAC 评分玻璃酸钠结合乙哌立松治疗组均显著低于两单独用药组；尿中 CTX-Ⅱ水平玻璃酸钠结合乙哌立松治疗组明显低于两单独用药组，差异有显著性（P ＜0．05）。结论通过2种不同药理作用的联合---玻璃酸钠的黏弹性充填作用与乙哌立松的缓解疼痛及痉挛作用，可使对膝关节骨关节炎的临床疗效明显优于单药应用。Abstract: Objective To compared the efficacy of hyaluronan combined with eperisone hy-drochloride or simple application of hyaluronan or eperisone hydrochloride in the treatment of pa-tients with knee osteoarthritis (OA).Methods 99 patients with knee OA were randomly divided into hyaluronan group,eperisone hydrochloride group and combined group (hyaluronan combined with eperisone hydrochloride),33 cases in each group.Efficacy was compared among 3 groups. Rsults 5 weeks after treatment,WOMAC score of combined group was significantly higher than hyaluronan group and eperisone hydrochloride group.The CTX-Ⅱ content of urine in combined group was significantly lower than the other two groups (P <0.05).Conclusion Combination of hyaluronan and eperisone hydrochloride can significantly improve the clinical symptoms of patients with knee OA,and its efficacy is obviously better than simple application of hyaluronan or eperisone hydrochloride.
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Keywords:
- knee osteoarthritis /
- hyaluronan /
- eperisone hydrochloride /
- CTX-Ⅱ
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期刊类型引用(2)
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2. 郭建懿，王晓林，郝晓飞，杜娟，武星光. 肺炎支原体肺炎患儿血清总IgE、CCSP、TIM-3与病情严重程度和预后的关系研究. 现代生物医学进展. 2024(17): 3279-3283 . 百度学术
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