Influence of Bushen Huayu decotion combined with diane-35 on MCP-1 level and blood lipids of patients with polycystic ovary syndrome
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摘要: 目的：观察补肾化瘀方联合达英-35治疗多囊卵巢综合征（PCOS）的临床疗效，并探讨其对血清单核细胞趋化蛋白-1（MCP-1）及血脂的影响。方法本院2008年7月-2012年4月住院治疗的55例 PCOS 患者随机分为2组，对照组（n ＝27例）仅采用达英-35治疗，观察组（n ＝28例）采用补肾化瘀方和达英-35联合治疗，观察和比较2组患者治疗前后 MCP-1、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白（HDL-C）水平的变化，以及各组临床疗效和不良反应。结果观察组治疗总有效率（82．1％）明显高于对照组（66．7％），P ＜0．05；2组患者治疗后血清 MCP-1、TC、TG 水平较治疗前均明显下降（P ＜0．05），而 HDL-C 较治疗前明显升高（P ＜0．05），且观察组各指标改善程度明显优于对照组（P ＜0．05）；2组治疗过程中均未出现严重不良反应。结论补肾化瘀方联合达英-35治疗 PCOS 疗效显著，其作用机制可能为抑制 MCP-1的分泌，降低血脂而取得良好的临床疗效。
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关键词:
- 补肾化瘀方 /
- 多囊卵巢综合征 /
- 达英-35 /
- 血清单核细胞趋化蛋白-1 /
- 血脂
Abstract: Objective To observe the clinical effect of Bushen Huayu decoction combined with diane-35 on the treatment of patients with polycystic ovary syndrome (PCOS)and explore its influence on serum MCP-1 level and blood lipids.Methods 55 patients with PCOS were randomly divided into the control group (n =27,treated with diane-35)and observation group (n =28, treated with Bushen Huayu decoction and diane-35).Levels of MCP-l,TC,TG and HDL-C before and after treatment were observed and compared,and the clinical efficacy and adverse reactions were observed as well.Results Total effective rate of observation group was 82.1%,which was significantly higher than 66.7% of control group (P <0.05).Levels of serum MCP-1,TC,TG decreased significantly after treatment in both groups (P <0.05 ),while HDL-C increased signifi-cantly (P <0.05).Improvement of all the indexes in the observation group were significantly bet-ter than those of control group(P <0.05).No severe adverse reactions were observed in both groups.Conclusion Bushen Huayu decoction combined with diane-35 can effectively inhabit the secretion of MCP-1 and reduce blood lipid in patients with PCOS. -
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