Abstract: Objective To study the clinical curative effect of continuous intrathecal injec-tion of vancomycin controlled by microinjection pump in the treatment of intracranial infection. Methods 50 patients with intracranial infections from January 2009 to October 2012 were includ-ed in the research.22 patients treated with cerebrospinal fluid drainage from lumbar cistern and discontinuous intrathecal injection of vancomycin were in control group,and another 28 patients with continuous intrathecal injection of vancomycin by micropump were in the experimental group. Therapeutic effect was observed between the two groups.Results The patients in the control group improved more rapidly than those in the experimental group in the temperature,blood,cere-brospinal fluid and other observation index.Compared with the control group,the pain of lower back and leg,convulsions,headache and other side effects were significantly reduced in the experi-mental group.Conclusions Continuous drainage of cerebrospinal fluid in lumbar cistern and mi-croinjection pump control continuous intrathecal injection of vancomycin is a safe and effective method to treat intracranial infection.