瑞芬太尼、芬太尼在肥胖患者麻醉中的应用观察

韦克; 邓军; 黄仕英

doi:10.7619/jcmp.201407032

瑞芬太尼、芬太尼在肥胖患者麻醉中的应用观察

右江民族医学院附属医院麻醉科，广西百色，533000

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中图分类号: R614
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出版历程
- 发布日期: 2014-07-14

Observation of application of remifentanil and fentanyl in obese patients during anesthesia period

摘要

摘要: 目的：观察瑞芬太尼、芬太尼在肥胖患者麻醉中的有效性和安全性。方法选择本院2012年10月-2013年10月拟全身麻醉手术的肥胖患者96例，采用隐藏数字随机法分为3组，每组32例，分别采用瑞芬太尼、芬太尼、瑞芬太尼复合芬太尼麻醉，比较3组血流动力学，采用视觉模拟评分（VAS）和镇静/警觉评分（OAA /S）。结果诱导前、插管前3组患者MAP 比较差异无统计学意义（P ＞0．05）。插管后芬太尼 MAP 明显升高，与瑞芬太尼组、联合组比较差异有统计学意义（P ＜0．05），拔管时瑞芬太尼组 MAP 明显升高，与芬太尼组、联合组比较差异有统计学意义（P ＜0．05）。瑞芬太尼组 VAS 评分明显高于芬太尼组、联合组，芬太尼组 OAA /S 评分明显低于瑞芬太尼组、联合组，组间比较差异有统计学意义（P ＜0．05）。结论肥胖患者麻醉中瑞芬太尼复合芬太尼在有效性与安全性方面具有较大优势。
- 瑞芬太尼 /
- 芬太尼 /
- 肥胖 /
- 麻醉
Abstract: Objective To explore the efficacy and safety of remifentanil and fentanyl in obese patients.Methods 96 obese patients applied general anesthesia in our hospital from October 2012 to October 2013 were randomly equally divided into three groups by hidden numbers.They were used remifentanil,fentanyl,remifentanil fentanyl fentanyl anesthesia.The hemodynamics was compared in the three groups,using the visual analogue scale (VAS)and sedation /alertness score (OAA /S).Results Before induction,the difference was not significant in intubation MAP of three groups (P >0.05).MAP significantly increased after intubation in fentanyl group, compared with the combined group and remifentanil group .The difference was significant . (P <0.05).Compared with the fentanyl group,MAP in extubation remifentanil group signifi-cantly increased.joint group difference was significant (P <0.05).VAS score in Remifentanil group was significantly higher than that in the fentanyl group,OAA /S score in combined group and the fentanyl group was significantly lower than that in remifentanil group.The difference was significant with the comparison of different groups.(P <0.05).Conclusion The efficacy and safety of remifentanil and fentanyl anesthesia in obese patients have greater advantages.
- remifentanil /
- fentanyl /
- obese patients /
- anesthesia