Correlation between angiotensin Ⅱand plasma adiponectin levels in patients with coronary heart disease
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摘要: 目的：对血管紧张素Ⅱ对冠心病患者血浆脂联素水平的影响进行观察和分析。方法以本院心内科2011-2012年收治的56例冠心病患者和48例健康者作为研究对象，分别对其进行血浆脂联素水平的检测，并对结果进行比较分析。结果①2组患者在性别、年龄、血糖、血压、（血清总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）差异均无统计学意义（P ＞0．05），而观察组患者脂联素和血管紧张素Ⅱ水平则显著高于对照组（P ＜0．01）；②观察组中急性冠脉综合征（ACS）和稳定性心绞痛（SAP）患者的血管紧张素Ⅱ水平均明显高于对照组，SAP 患者的脂联素水平高于对照组，而 ACS 患者其脂联素明显低于对照组患者和 SAP 患者（P ＜0．05），差异均具有统计学意义。结论血管紧张素Ⅱ和脂联素水平变化与冠心病发病以及冠脉的稳定性有着密切的关系，临床可通过抑制血管紧张素Ⅱ的生成，促进脂联素的分泌，起到提高冠脉稳定性的作用。Abstract: Objective To explore the correlation between angiotensin Ⅱ and the levels of plasma adiponectin in patients with coronary heart disease (CHD).Methods 56 patients with CHD and 48 healthy peoples were collected as research object,and the plasma adiponectin levels were detected and compared between two groups.Results There were no significant differences of gender,age,blood glucose,blood pressure,TC and LDL-C between two groups (P >0.05), but adiponectin and angiotensin Ⅱ levels of the observation group were significantly higher than those of control group (P <0.01).The angiotensin Ⅱ levels in ACS and SAP patients of observa-tion group were significantly higher than that of control group,the adiponectin level of SAP pa-tients was higher than that of the control group,and the adiponectin level of ACS patients was sig-nificantly lower than that of the control group and SAP patients(P <0.05).Conclusion There is a close relationship between levels of angiotensin Ⅱ,adiponectin and the attack of the coronary dis-ease,the stability of the coronary artery.In the clinic,physicians can inhibit the formation of an-giotensin Ⅱ to promote the secretion of adiponectin and improve the stability of coronary artery.
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Keywords:
- angiotensin Ⅱ /
- adiponectin /
- coronary heart disease
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