Changes of blood lipid levels in patients with multiple myeloma and its clinical significance
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摘要: 目的：探讨多发性骨髓瘤（MM）患者血脂变化及其与临床分期的关系。方法选取本院收治的112例初诊 MM患者作为 MM 组，同时选取80例正常体检者作为正常对照组，比较2组化疗前的血脂水平，不同分期 MM 患者血脂水平及其化疗前后的血脂水平，包括甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）。结果化疗前，MM 组血清 TC、HDL-C 及 LDL-C 水平均明显低于正常对照组，而 TG 水平与正常对照组比较差异无统计学意义。Ⅲ期患者血清 TC、HDL-C 和 LDL-C 水平均明显低于正常对照组，Ⅱ期患者血清 LDL-C 水平明显低于正常对照组，而Ⅰ期患者血脂水平与正常对照组比较差异无统计学意义。经2个疗程化疗后，治疗有效者 TC 及 HDL-C 水平明显高于化疗前。结论血脂水平可以辅助 MM 的诊断及对临床分期和预后的判断。Abstract: Objective To investigate the changes of blood lipid in the patients with multiple myeloma (MM)and the relationship with clinical stage.Methods 112 initially-diagnosed patients with MM and 80 healthy people were respectively as MM group and normal control group.The lev-els of blood lipid before chemotherapy in two groups and MM patients with different clinical stages as well as the levels before and after chemotherapy were compared.Triglyceride (TG),total choles-terol (TC),high density lipoprotein cholesterol (HDL-C)and low density lipoprotein cholesterol (LDL-C)were included.Results Before chemotherapy,the levels of TC,HDL-C and LDL-C in MM group were significantly lower than that in normal control group,but the difference was not significant compared with TG levels.The levels of TC,HDL-C and LDL-C in phase Ⅲ and LDL-C in phase Ⅱ were all significantly lower than that in normal control group,and the difference was not significant compared with the levels of blood lipid in phase Ⅰ.After 2 courses of chemotherapy,the levels of TC and HDL-C in effectively treated patients were obviously higher than that before chemotherapy.Conclusion The level of blood lipid is helpful to diagnose patients with MM and to evaluate the clinical staging and prognosis.
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Keywords:
- multiple myeloma /
- changes of blood lipid /
- clinical stage /
- chemotherapy
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期刊类型引用(15)
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