Abstract: Objective To compare the clinical efficacy of percutaneous endoscopic gastrosto-my(PEG)and nasogastric feeding tube in the treatment of Crohn’s disease patients with malnutrition. Methods Clinical materials of 45 patients underwent enteral nutrition for CD from 2007 to 2013 were analyzed,and they were divided into PEG group (n =24)and nasogastric feeding group (n =21 ). Results The rate of tube-associated complications was 16.67% in the PEG group, which was significantly lower than 4 7 .6 2 % in the nasogastric feeding group (χ2 =5 .0 0 7 ,P =0 .0 2 5 ).There was no significant difference of nutrition improvement between the two group (P >0.05).One month after treatment,IBDQ score in the PEG group was significantly higher than that in the nasogastric feeding group (P <0.05 ).Conclusion PEG is a safe,effective and comfortable method for CD patients who need to be treated with a long-term enteral nutrition.